Nicotinamide

Nicotinamide Molecule

Nicotinamide: The key molecule in Energy Production

Nicotinamide, coupled with the nucleotide adenine, is a molecule involved in reduction-oxidation reactions in metabolic pathways. It acts as a hydrogen carrier which in turn, produces ATP – the energy currency of the cell. ATP is required by cells in performing important functions required for survival. Moreover, it is also plays a vital role in detoxifying cells from free radicals and toxic chemicals, as well as in DNA repair processes. Nicotinamide is obtained from dietary sources rich in Vitamin B3 such as lean meat, eggs, dairy and poultry products, mushrooms and nuts.It is also included in pre-workout formulas in order to maximize cellular fuels thereby optimizing biochemical reactions. Not to confuse with Niacin (another form of Vitamin B3 involved in lowering cholesterol), Nicotinamide contains an amide functional group instead of carboxylic acid (functional group of Niacin).

What does Nicotinamide look like in Chemistry?

Nicotinamide Molecule

Let’s Get Building!

Using your Student Molecular Set from Duluth Labs let’s create Nicotinamide! You’ll need:

  • 6 Carbon Atoms
  • 2 Nitrogen Atoms
  • 1 Oxygen Atoms
  • 6 Hydrogen Atoms
  • 6 Small connectors (compact small bonds for hydrogen)
  • 5 Medium Connectors
  • 8 Long connectors
  • Molecular Tool (for Disassembly) 

Put aside all the atoms and connectors needed.

Let’s Start Building With Our Pyridine Portion!

Nicotinamide Molecule

Note: Let’s begin with Carbon 4! We start building this portion of the molecule in a counterclockwise direction.

Let’s start!

Steps:

  • 1
    Nicotinamide Molecule

    1. Get one carbon atom (Carbon 4)then attach another carbon atom (Carbon 5)to it using 1 medium connector. Add a hydrogen atom on both carbons (Carbon 4 and Carbon 5) using 2 small connectors.

  • 2
    Nicotinamide Molecule

    2. Attach another carbon (Carbon 6) below Carbon 5using 2 long connectors. Place a hydrogen atom on Carbon 6 using a small connector.

  • 3
    Nicotinamide Molecule

    3. Then, get anitrogen atom(Nitrogen 1)and attach this to Carbon 6 using 1 medium connector.

  • 4
    Nicotinamide Molecule

    4. Add another carbon atom (Carbon 2) then attach this to Nitrogenusing 2 long connectors. Place a hydrogen atom on Carbon 2 using a small connector.

  • 5
    Nicotinamide Molecule

    5. Get another carbon atom (Carbon 3) then attach this to Carbon 2using 1 medium connector.

  • 6
    Nicotinamide Molecule

    6. Join Carbon 3 and carbon 4 together using 2 long connectors.

  • Nicotinamide Molecule

    Yay! We've just built our Pyridine Portion!

Note: Let’s now continue adding the amide functional group on the Carbon at Position 3.

Nicotinamide Molecule

Steps:

  • 1
    Nicotinamide Molecule

    1. Get one Carbon atom then attach this to Carbon 3 of the pyridine portion using a medium connector.

  • 2
    Nicotinamide Molecule

    2. Add an Oxygen atom on this carbonusing 2 long connectors.

  • Nicotinamide Molecule

    3. Then, attach a Nitrogen atom on this carbon using a medium connector. Place2 hydrogen atomsonthenitrogen using 2 small connectors

Great work! Now we have our newly-built Nicotinamide molecule.

Feel free to show us how your Nicotinamide turned out!


Comment and share pictures below!

Tune in next week for another Molecule of the week!

See you then xoxo :)

Duluth Labs

Afton Direct LLC

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