Hydroxyproline

January 10, 2018

HYDROXYPROLINE: Maintains elasticity and structure

Have you ever wondered what type of protein is most abundant in your body? Collagen is the major protein found in mammals, and it makes up most of the elastic tissues in the body such as the tough inner layer of the skin, mucous membranes, nerves, blood vessels, and organs. Drinking and injecting collagen-based supplements has lived up to the hype nowadays due to some claims that it makes skin more elastic.

But what makes collagen strong?

Collagen consists of a derived amino acid called hydroxyproline which maintains its conformational rigidity. Hydroxyproline (HP) and proline(P) residues allow twisting of the amino acid chain helix which imparts sufficient stability. These multiple networks of HP and P residues combine together to form the elastic protein we know today as Collagen. This tough and flexible protein is responsible for making our tendons and ligaments strong enough to support our bones.

How does Hydroxyproline look like in Chemistry?

Let’s Get Building!

Using your Student Molecular Set from Duluth Labs let’s create Hydroxyproline! You’ll need:

5 Carbon atoms
3 Oxygen atoms
9 Hydrogen atoms
1 Nitrogen atom
9 Small Connectors (compact small bonds for hydrogen)
4 Medium Connectors
2 Long Connectors
Molecular Tool (for Disassembly)

Put aside all the atoms and connectors needed.

Let’s Start Building With Our Nitrogen 1!

Steps:

1

1. Get one nitrogen atom (Nitrogen 1)then, attachan hydrogen atom to it using a medium connector.
2

2. Take one carbon atom (Carbon 2) then attach this to Nitrogen 1 using a medium connector. Place a hydrogen atom on Carbon 2 using a small connector.
3

3. Attach a carbon atom (Carbonyl carbon)to Carbon 2 using a medium connector.
4

4. Get an Oxygen atom and attach this to the Carbonyl carbon using 2 Long connectors.
5

5. Attach an Oxygen atom to the Carbonyl carbon using a medium connector. Then, place a hydrogen atom on the carbonyl carbon using a small connector.
6

6. Attach a carbon atom (Carbon 3)then attach this to Carbon 2 using a medium connector. Then, place two hydrogen atoms to Carbon 3 using 2 small connectors.
7

7. Get a carbon atom (Carbon 4) and attach this toCarbon 3 using a medium connector. Then, attach a hydrogen atom to Carbon 4 using a small connector.
8

8. Take your Oxygen atom to this Carbon 4 using a medium connector.Place a hydrogen atom on this oxygen using a small connector.
9

9. Grab the last carbon atom(Carbon 5) then attach this to the Carbon 4using a medium connector. Add two hydrogen atoms on Carbon 5 using 2 small connectors.
10

10. Join Carbon 5 and Nitrogen 1 together using a medium connector.

Great work! Now we have our newly-built Hydroxyproline molecule.

Feel free to show us how your hydroxyproline turned out!

Comment and share pictures below!

Tune in next week for another Molecule of the week!

See you then xoxo :)

Duluth Labs

Afton Direct LLC

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