Calcitriol

Calcitriol Molecule duluth labs

Calcitriol: The Key to Stronger Bones 

Calcitriol (Vitamin D3) is a steroid hormone that is important in the regulation of Calcium and Phosphorus absorption. It is produced mainly in the kidneys upon the activation of UV rays. The precursor of Calcitriol is cholecalciferol, which is abundant in the skin. Cholecalciferol is not readily used by the body and requires conversion to Calcitriol for it to become more active and useful for body processes. Reaction with UV rays is required for its conversion to calcitriol, hence exposure to enough sunlight (especially during the early morning sun – from 7AM to 9AM) would be necessary for it to be activated. Once activated, it can readily pass through the membranes of the intestinal tract and pass through the bloodstream where it elicits its effect on the regulation of calcium absorption. Calcitriol promotes absorption of calcium in the bones, making them stronger and healthier.

What does Calcitriol look like in Chemistry?

Calcitriol Molecule

Let’s Get Building!

Using your Student Molecular Set from Duluth Labs let’s create Calcitriol! You’ll need:

  • 27 Carbon Atoms

  • 3 Oxygen Atoms

  • 44 Hydrogen Atoms

  • 44 Small Connectors (compact short bonds for hydrogen)

  • 29 Medium Connectors

  • 6 Long Connectors

  • Molecular Tool (for Disassembly)

Put aside all the atoms and connectors needed.

Note: You will need more than one Student Molecular Set from Duluth Labs to create Calcitriol Molecule. 

Let’s Start Building With Our Ring A Portion! 

Calcitriol Molecule

Note: Let’s begin with Carbon 5! We start building this portion of the molecule in a clockwise direction.

Let’s start!

Steps:

  • 1
    Calcitriol Molecule

    1. Get one carbon atom (Carbon 5) then attach another carbon atom (Carbon 10) to it using 1 medium connector.

  • 2
    Calcitriol Molecule

    2. Then, get another carbon atom (Carbon 19) then attach this to Carbon 10 using 2 long connectors. Attach 2 hydrogen atoms to carbon 19 using 2 short connectors.

  • 3
    Calcitriol Molecule

    3. Get another carbon (Carbon 1) and attach this below Carbon 10 using 1 medium connector. Add a hydrogen atom on Carbon 1 using a small connector.

  • 4
    Calcitriol Molecule

    4. Attach one Oxygen atom to Carbon 1 using a medium connector. Note that the oxygen atom should be positioned towards you. Likewise, add 1 hydrogen atom on this oxygen using a small connector.

  • 5
    Calcitriol Molecule

    5. Get another carbon atom (Carbon 2) then attach this to Carbon 1 using a medium connector. Place a 2 hydrogen atoms on Carbon 2 using 2 small connectors

  • 6
    Calcitriol Molecule

    6. Get another carbon atom (Carbon 3) then attach this to Carbon 2 using a medium connector. Add one hydrogen atom to carbon 3 using a small connector.

  • 7
    Calcitriol Molecule

    7. Attach one Oxygen atom to Carbon 3 using a medium connector. Note that the oxygen atom should be positioned away from you. Likewise, add 1 hydrogen atom to this oxygen using a small connector.

  • 8
    Calcitriol Molecule

    8. Get one carbon atom (Carbon 4) then attach this above Carbon 3 using a medium connector. Add 2 hydrogen atoms o this carbon using 2 small connectors.

  • 9
    Calcitriol Molecule

    9. Join Carbon 4 and Carbon 5 together using a medium connector.

  • 10
    Calcitriol Molecule

    Yay! We've just built our Cyclohexanediol Portion!

Note: Let’s now continue building the Ring C of Calcitriol, starting with Carbon 12. We start building this portion of the molecule in a counterclockwise direction.

Calcitriol Molecule

Steps:

  • 1
    Calcitriol Molecule

    1. Get one Carbon atom (Carbon 12) then add 2 hydrogen atoms to this carbon using 2 small connectors. Attach Carbon 12 to another carbon (Carbon 11) using a medium connector. Likewise, add 2 hydrogen atoms on Carbon 11 using 2 small connectors.

  • 2
    Calcitriol Molecule

    2. Get another carbon atom (Carbon 9) then attach this to Carbon 11 using a medium connector. Add 2 hydrogen atoms on this carbon using 2 small connectors.

  • 3
    Calcitriol Molecule

    3. Attach another carbon atom (Carbon 8) to Carbon 9 using 1 medium connector.

  • 4
    Calcitriol Molecule

    4. Get one carbon atom (Carbon 14) then attach this to Carbon 8 using a medium connector. Place 1 hydrogen atom on Carbon 14 using a small connector.

    Note: the hydrogen should be positioned away from you.

  • 5
    Calcitriol Molecule

    5. Attach one carbon atom (Carbon 13) above Carbon 14 using 1 medium connector. Then, place a carbon atom (Carbon 18) above Carbon 13 using 1 medium connector. Add 3 hydrogens on Carbon 18 using 3 small connectors.

  • 6
    Calcitriol Molecule

    6. Join Carbon 12 and Carbon 13 together using 1 medium connector

  • Calcitriol Molecule

    Yay! We've just built our Ring C Portion!

Note: Oops! We’re not through yet with our fused rings. Let’s get this done! We will now work on Ring D, starting with Carbon 17. We start building this portion of the molecule in a clockwise direction.

Calcitriol Molecule

Steps:

  • 1
    Calcitriol Molecule

    1. Get one carbon atom (Carbon 17) then attach this to Carbon 13 using a medium connector. Add a hydrogen on Carbon 17 using a small connector.

  • 2
    Calcitriol Molecule

    2.Add another carbon atom (Carbon 16) to Carbon 17 using 1 medium connector. Place 2 hydrogen atoms on Carbon 16 using 2 small connectors.

  • 3
    Calcitriol Molecule

    3. Attach another carbon atom (Carbon 15) to Carbon 16 using 1 medium connector. Place 2 hydrogen atoms on this carbon using 2 small connectors.

  • 4
    Calcitriol Molecule

    4. Join Carbons 15 and 14 using 1 medium connector.

  • Calcitriol Molecule

    Yay! We've just built our Ring D Portion!

Note: We’re almost down to our last step – the addition of saturated alcohol chain! We start with Carbon 20 until we reach carbon 26!

Calcitriol Molecule

Steps:

  • 1
    Calcitriol Molecule

    1. Get one carbon atom (Carbon 20) then attach this to Carbon 17 using a medium connector. Then, place a hydrogen atom to this carbon using a small connector.

  • 2
    Calcitriol Molecule

    2. Attach another carbon atom (Carbon 21) on the left of Carbon 20 using 1 medium connector. Place 3 hydrogen atoms on Carbon 21 using 3 small connectors.

  • 3
    Calcitriol Molecule

    3. Attach another carbon atom (Carbon 22) to the right of Carbon 20 using 1 medium connector. Place 2 hydrogen atoms on this carbon using 2 small connectors.

  • 4
    Calcitriol Molecule

    4. Attach another carbon atom (Carbon 23) next to Carbon 22 using 1 medium connector. Place 2 hydrogen atoms on this carbon using 2 small connectors

  • 5
    Calcitriol Molecule

    5. Add one carbon atom (Carbon 24) on the right of Carbon 23 using 1 medium connector. Likewise, place 2 hydrogen atoms on this carbon using 2 small connectors.

  • 6
    Calcitriol Molecule

    6. Attach one carbon atom (Carbon 25) to the right of Carbon 24 using 1 medium connector.

  • 7
    Calcitriol Molecule

    7. Place 2 carbon atoms on Carbon 25 using 2 medium connectors. Then, add 3 hydrogen atoms on each Carbon using 6 small connectors

  • 8
    Calcitriol Molecule

    8. Finally, get one Oxygen atom then attach this to Carbon 25 using a medium connector. Place one hydrogen atom on this oxygen using a small connector

  • Calcitriol Molecule

    Yay! We've just built our methylheptanol portion!

Note: Finally! We’re now on to our last step – joining of Rings A, C and D.

Steps:

  • 9
    Calcitriol Molecule

    9.Get one carbon atom (Carbon 6) then attach this above Carbon 5 using 2 long connectors. Then, place a hydrogen atom on this carbon using a small connector

  • 10
    Calcitriol Molecule

    10. Attach another carbon atom (Carbon 7) next to Carbon 6 using 1 medium connector. Likewise, add 1 hydrogen atom on this carbon using 1 small connector.

  • Calcitriol Molecule

    11. Finally, join Carbon 7 and Carbon 8 together using 2 long connectors.

Great work! Now we have our newly-built Calcitriol molecule.

Feel free to show us how your Calcitriol turned out!


Comment and share pictures below!

Tune in next week for another Molecule of the week!

See you then xoxo :)

Duluth Labs

Afton Direct LLC


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